Arnav Mehta
Arnav Mehta

Arnav Mehta

MD, PhD

I am a physician scientist, gastrointestinal oncologist, biotech entrepreneur and investor committed to making better therapies for all patients.

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About

I am currently a Venture Partner at The Column Group, a Co-Founder of Monimoi Therapeutics and a gastrointestinal oncologist at Stanford University School of Medicine. In addition, I am a Board Director for Monimoi Therapeutics and SyntheX, a Board Observer for Plexium, and serve advisory roles as an Entrepreneur-in-Residence at the Arc Institute, on the SAB for CxT Discovery and as a member of the Industry Consortium for Reversing Early Recurrence. As a physician scientist, I'm interested in immunology, cancer biology, single-cell genomics, mathematics and machine learning, applied to the discovery of new cancer therapies. Clinically, I primarily see gastric and pancreatic cancer patients.

Prior to my current role, I was a researcher at the Broad Institute running an independent group alongside Eric Lander and Nir Hacohen's labs, a gastrointestinal oncologist at the Massachusetts General Hospital (MGH) Cancer Center and an Entrepreneur in Residence (EIR) at Third Rock Ventures, where I was part of the founding teams for Abata Therapeutics, Asher Biotherapeutics and Clasp Therapeutics. I completed my hematology/oncology fellowship at the Dana Farber Cancer Institute (DFCI) and MGH, and my internal medicine residency at MGH as part of the Stanbury Physician Scientist Pathway (PSP).

I was born in New Delhi, India and raised in Hong Kong and Singapore before moving to Florida at the beginning of my sophomore year of high school. I did my undergraduate degree at Duke University studying pure and applied math, and chemistry. I subsequently completed my MD at David Geffen School of Medicine at UCLA and my PhD at Caltech with David Baltimore.

Current Roles

The Column Group

Venture Partner

Stanford University School of Medicine

Adjunct Clinical Assistant Professor

Board Roles

Monimoi Therapeutics

Co-Founder and Board Director

SyntheX

Board Director

Plexium

Board Observer

Additional Affiliations

Broad Institute

Visiting Scientist

Arc Institute

Entrepreneur in Residence

Reversing Early Recurrence

Industry Consortium Member

CxT Discovery

Scientific Advisory Board

Research Interests

I have a multidisciplinary clinical, experimental, and computational background. My research spans data science and machine learning, single cell and spatial transcriptomics, functional genomics and lineage tracing, image based screening (such as optical pooled screens), pre-clinical tumor models and translational oncology.

Select Publications

From 60+ publications. View all publications on PubMed or Google Scholar.

Transcriptomic Plasticity Is a Hallmark of Metastatic Pancreatic Cancer

Jiménez-Sánchez, A., Persad, S., Hayashi, A., Umeda, S., Sharma, R., Xie, Y., Mehta, A., Park, W., Masilionis, I., Pe'er, D.

Cancer Research2026

Distinct Spatially Resolved Tumor Microenvironment Trajectories Define Benefit from Ramucirumab plus Pembrolizumab in Refractory PD-L1+ Gastric Cancer

Lim, S.H., An, M., Heo, Y.J., Lee, H., Min, B.H., Mehta, A., Ahn, S., Kim, K.M., Kim, S.T., Klempner, S.J., Lee, J.

Cancer Immunology Research2026

Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics

Avraham-Davidi, I., Mages, S., Klughammer, J., Moriel, N., Imada, S., Hofree, M., Murray, E., Chen, J., Pelka, K., Mehta, A., Delorey, T., Caplan, L., Dionne, D., Strasser, R., Lalakova, J., Niesnerova, A., Xu, H., Rouault, M., Tirosh, I., Hacohen, N., Chen, F., Yilmaz, O., Roper, J., Rozenblatt-Rosen, O., Nitzan, M., Regev, A.

eLife2025

Overcoming resistance to immunotherapy by targeting CD38 in human tumor explants

Revach, O.Y., Cicerchia, A.M., Shorer, O., Palin, C.A., Petrova, B., Anderson, S., Liu, B., Park, J., Chen, L., Mehta, A., Wright, S.J., Jenkins, R.W.

Cell Reports Medicine2025

Multimodal blood based profiling reveals insights into mechanisms of immunotherapy resistance

Wright, S.J., Zamora, I., Parikh, M., Yeramosu, D., Rucevic, M., Sade-Feldman, M., LaSalle, T.J., Blaum, E.M., Liu, B., Bi, L., Kang, S., Blum, S.M., Nguyen, N., Guess, J., Kar, A., Schneider, A., Lieb, D., Woods, E., Michaud, W., Lawless, A.R., Sharova, T., Cohen, S., Kasumova, G., Kim, M.S., Villani, A.C., Park, R.J., Jenkins, R.W., Klempner, S.J., Sullivan, R.J., Flaherty, K.T., Hacohen, N.*, Mehta, A.*, Boland, G.M.*

medRxiv2025

TBK1 Targeting Is Identified as a Therapeutic Strategy to Enhance CAR T-Cell Efficacy Using Patient-Derived Organotypic Tumor Spheroids

Sun, Y., Maggs, L., Panda, A., Wright, S.J., Cicerchia, A.M., Jenney, A., Perricone, M.D., Mills, C.E., Cattaneo, G., Ventin, M., Chen, F., Rasmussen, M.Q., Miranda, A., Revach, O.Y., Fang, J., Fu, A., Bowling, P.J., Sharova, T., Lawless, A., Sorger, P.K., Bardeesy, N., Wang, X., Flaherty, K.T., Boland, G.M., Mehta, A., Sade-Feldman, M., Ferrone, C.R., Jenkins, R.W.

Cancer Immunology Research2025

Melanoma to rhabdomyosarcoma plasticity in the setting of immunotherapy

Knight, A.D., Robitschek, E.J., Lin, J.R., Frederick, D.T., Shi, A., Larque, A.B., Miao, B., Raghavan, R.S., Sharova, T., Shin, J.H., Sorger, P., Kellis, M., Flaherty, K.T., Hacohen, N., Boland, G.M., Chebib, I., Liu, D.*, Sullivan, R.J.*, Mehta, A.*

medRxiv2025

Differential T cell clonal dynamics underlie outcomes to frontline chemoimmunotherapy in advanced gastric cancer

Wright, S.J., Kang, S., An, M., Heo, Y.J., Parikh, M., Bi, L., Lee, H., Moorehead, G., Haradhvala, N., Lim, S.H., Kim, S.T., Getz, G., Hacohen, N., Lee, J., Mehta, A.*, Klempner, S.J.*, Park, R.J.*

medRxiv2025

Characterization of cell states in biliary tract cancers identifies mechanisms of therapeutic resistance in a phase II trial of DKN-01/nivolumab

Park, R.J., Parikh, M., Pappas, L., Sade-Feldman, M., Kulkarni, A.S., Bi, L., LaSalle, T.J., Galway, A., Kuhlman, C., Blaszkowsky, L.S., Meyerhardt, J.A., Enzinger, P.C., Biller, L., Allen, J.N., Kagey, M.H., Baum, J., Sirard, C., Duda, D.G., Zhu, A.X., Abrams, T.A., Hacohen, N., Ting, D.T., Mehta, A.*, Goyal, L.*

medRxiv2024

Early Immune Remodeling Steers Clinical Response to First-Line Chemoimmunotherapy in Advanced Gastric Cancer

An, M.*, Mehta, A.*, Min, B.H., Heo, Y.J., Wright, S.J., Parikh, M., Bi, L., Lee, H., Kim, T.J., Lee, S.Y., Moon, J., Park, R.J., Strickland, M.R., Park, W.Y., Kang, W.K., Kim, K.M., Kim, S.T., Klempner, S.J., Lee, J.

Cancer Discovery2024

Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy

Chen, J.H., Nieman, L.T., Spurrell, M., Jorgji, V., Elmelech, L., Richieri, P., Xu, K.H., Madhu, R., Parikh, M., Zamora, I., Mehta, A., Nabel, C.S., Freeman, S.S., Pirl, J.D., Lu, C., Meador, C.B., Barth, J.L., Sakhi, M., Tang, A.L., Sarkizova, S., Price, C., Fernandez, N.F., Emanuel, G., He, J., Van Raay, K., Reeves, J.W., Yizhak, K., Hofree, M., Shih, A., Sade-Feldman, M., Boland, G.M., Pelka, K., Aryee, M.J., Mino-Kenudson, M., Gainor, J.F., Korsunsky, I., Hacohen, N.

Nature Immunology2024

Lineage Plasticity: The New Cancer Hallmark on the Block

Mehta, A., Stanger, B.Z.

Cancer Research2024

Combined PD-1, BRAF and MEK inhibition in BRAF(V600E) colorectal cancer: a phase 2 trial

Tian, J., Chen, J.H., Chao, S.X., Pelka, K., Giannakis, M., Hess, J., Burke, K., Jorgji, V., Sindurakar, P., Braverman, J., Mehta, A., Oka, T., Huang, M., Lieb, D., Spurrell, M., Allen, J.N., Abrams, T.A., Clark, J.W., Enzinger, A.C., Enzinger, P.C., Klempner, S.J., McCleary, N.J., Meyerhardt, J.A., Ryan, D.P., Yurgelun, M.B., Kanter, K., Van Seventer, E.E., Baiev, I., Chi, G., Jarnagin, J., Bradford, W.B., Wong, E., Michel, A.G., Fetter, I.J., Siravegna, G., Gemma, A.J., Sharpe, A., Demehri, S., Leary, R., Campbell, C.D., Yilmaz, O., Getz, G.A., Parikh, A.R., Hacohen, N., Corcoran, R.B.

Nature Medicine2023

Targeting TBK1 to overcome resistance to cancer immunotherapy

Sun, Y., Revach, O.Y., Anderson, S., Kessler, E.A., Wolfe, C.H., Jenney, A., Mills, C.E., Robitschek, E.J., Davis, T.G.R., Kim, S., Fu, A., Ma, X., Gwee, J., Tiwari, P., Du, P.P., Sindurakar, P., Tian, J., Mehta, A., Schneider, A.M., Yizhak, K., Sade-Feldman, M., LaSalle, T., Sharova, T., Xie, H., Liu, S., Michaud, W.A., Saad-Beretta, R., Yates, K.B., Iracheta-Vellve, A., Spetz, J.K.E., Qin, X., Sarosiek, K.A., Zhang, G., Kim, J.W., Su, M.Y., Cicerchia, A.M., Rasmussen, M.Q., Klempner, S.J., Juric, D., Pai, S.I., Miller, D.M., Giobbie-Hurder, A., Chen, J.H., Pelka, K., Frederick, D.T., Stinson, S., Ivanova, E., Aref, A.R., Paweletz, C.P., Barbie, D.A., Sen, D.R., Fisher, D.E., Corcoran, R.B., Hacohen, N., Sorger, P.K., Flaherty, K.T., Boland, G.M., Manguso, R.T., Jenkins, R.W.

Nature2023

In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer

Dubrot, J., Du, P.P., Lane-Reticker, S.K., Kessler, E.A., Muscato, A.J., Mehta, A., Freeman, S.S., Allen, P.M., Olander, K.E., Ockerman, K.M., Wolfe, C.H., Wiesmann, F., Knudsen, N.H., Tsao, H.W., Iracheta-Vellve, A., Schneider, E.M., Rivera-Rosario, A.N., Kohnle, I.C., Pope, H.W., Ayer, A., Mishra, G., Zimmer, M.D., Kim, S.Y., Mahapatra, A., Ebrahimi-Nik, H., Frederick, D.T., Boland, G.M., Haining, W.N., Root, D.E., Doench, J.G., Hacohen, N., Yates, K.B., Manguso, R.T.

Nature Immunology2022

Early Tumor-Immune Microenvironmental Remodeling and Response to First-Line Fluoropyrimidine and Platinum Chemotherapy in Advanced Gastric Cancer

Kim, R.*, An, M.*, Lee, H.*, Mehta, A.*, Heo, Y.J., Kim, K.M., Lee, S.Y., Moon, J., Kim, S.T., Min, B.H., Kim, T.J., Rha, S.Y., Kang, W.K., Park, W.Y., Klempner, S.J., Lee, J.

Cancer Discovery2022

Radiation therapy enhances immunotherapy response in microsatellite stable colorectal and pancreatic adenocarcinoma in a phase II trial

Parikh, A.R., Szabolcs, A., Allen, J.N., Clark, J.W., Wo, J.Y., Raabe, M., Thel, H., Hoyos, D., Mehta, A., Arshad, S., Lieb, D.J., Drapek, L.C., Blaszkowsky, L.S., Giantonio, B.J., Weekes, C.D., Zhu, A.X., Goyal, L., Nipp, R.D., Dubois, J.S., Van Seventer, E.E., Foreman, B.E., Matlack, L.E., Ly, L., Meurer, J.A., Hacohen, N., Ryan, D.P., Yeap, B.Y., Corcoran, R.B., Greenbaum, B.D., Ting, D.T., Hong, T.S.

Nature Cancer2021

SARS-CoV-2 viremia is associated with distinct proteomic pathways and predicts COVID-19 outcomes

Li, Y., Schneider, A.M., Mehta, A., Sade-Feldman, M., Kays, K.R., Gentili, M., Charland, N.C., Gonye, A.L., Gushterova, I., Khanna, H.K., LaSalle, T.J., Lavin-Parsons, K.M., Lilley, B.M., Lodenstein, C.L., Manakongtreecheep, K., Margolin, J.D., McKaig, B.N., Parry, B.A., Rojas-Lopez, M., Russo, B.C., Sharma, N., Tantivit, J., Thomas, M.F., Regan, J., Flynn, J.P., Villani, A.C., Hacohen, N., Goldberg, M.B., Filbin, M.R., Li, J.Z.

Journal of Clinical Investigation2021

Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions

Filbin, M.R.*, Mehta, A.*, Schneider, A.M., Kays, K.R., Guess, J.R., Gentili, M., Fenyves, B.G., Charland, N.C., Gonye, A.L.K., Gushterova, I., Khanna, H.K., LaSalle, T.J., Lavin-Parsons, K.M., Lilley, B.M., Lodenstein, C.L., Manakongtreecheep, K., Margolin, J.D., McKaig, B.N., Rojas-Lopez, M., Russo, B.C., Sharma, N., Tantivit, J., Thomas, M.F., Gerszten, R.E., Heimberg, G.S., Hoover, P.J., Lieb, D.J., Lin, B., Ngo, D., Pelka, K., Reyes, M., Smillie, C.S., Waghray, A., Wood, T.E., Zajac, A.S., Jennings, L.L., Grundberg, I., Bhattacharyya, R.P., Parry, B.A., Villani, A.C., Sade-Feldman, M., Hacohen, N., Goldberg, M.B.

Cell Reports Medicine2021

Immunotherapy Resistance by Inflammation-Induced Dedifferentiation

Mehta, A., Kim, Y.J., Robert, L., Tsoi, J., Comin-Anduix, B., Berent-Maoz, B., Cochran, A.J., Economou, J.S., Tumeh, P.C., Puig-Saus, C., Ribas, A.

Cancer Discovery2018

Heterogeneous Responses of Hematopoietic Stem Cells to Inflammatory Stimuli Are Altered with Age

Mann, M.*, Mehta, A.*, de Boer, C.G.*, Kowalczyk, M.S.*, Lee, K., Haldeman, P., Rogel, N., Knecht, A.R., Farouq, D., Regev, A., Baltimore, D.

Cell Reports2018

A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment

Ng, K.K., Yui, M.A., Mehta, A., Siu, S., Irwin, B., Pease, S., Hirose, S., Elowitz, M.B., Rothenberg, E.V., Kueh, H.Y.

eLife2018

An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses

Mann, M., Mehta, A., Zhao, J.L., Lee, K., Marinov, G.K., Garcia-Flores, Y., Lu, L.F., Rudensky, A.Y., Baltimore, D.

Nature Communications2017

MicroRNAs as regulatory elements in immune system logic

Mehta, A., Baltimore, D.

Nature Reviews Immunology2016

Molecular Imaging of Brain Tumors Using Liposomal Contrast Agents and Nanoparticles

Mehta, A., Ghaghada, K., Mukundan, S.

Magnetic Resonance Imaging Clinics of North America2016

The microRNA-212/132 cluster regulates B cell development by targeting Sox4

Mehta, A., Mann, M., Zhao, J.L., Marinov, G.K., Majumdar, D., Garcia-Flores, Y., Du, X., Erikci, E., Chowdhury, K., Baltimore, D.

Journal of Experimental Medicine2015

The MicroRNA-132 and MicroRNA-212 Cluster Regulates Hematopoietic Stem Cell Maintenance and Survival with Age by Buffering FOXO3 Expression

Mehta, A., Zhao, J.L., Sinha, N., Marinov, G.K., Mann, M., Kowalczyk, M.S., Galimidi, R.P., Du, X., Erikci, E., Regev, A., Chowdhury, K., Baltimore, D.

Immunity2015

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